InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SYNE2

Summary

InnateDB Gene

IDBG-646766.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNE2

Gene Name

nesprin-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025450

Encoded Proteins

IDBP-699597

spectrin repeat containing, nuclear envelope 2

IDBP-699598

spectrin repeat containing, nuclear envelope 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054654:
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:76362023-76699213

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012582	ENSBTAP00000012582
ENSBTAT00000029285	ENSBTAP00000029285

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006998	nuclear envelope organization
GO:0007097	nuclear migration
GO:0007163	establishment or maintenance of cell polarity
GO:0010761	fibroblast migration
GO:0030335	positive regulation of cell migration
GO:0031022	nuclear migration along microfilament
GO:0034504	protein localization to nucleus
GO:0051642	centrosome localization
GO:0090286	cytoskeletal anchoring at nuclear membrane

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005925	focal adhesion
GO:0016021	integral component of membrane
GO:0016235	aggresome
GO:0016529	sarcoplasmic reticulum
GO:0030016	myofibril
GO:0030018	Z disc
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0031965	nuclear membrane
GO:0031981	nuclear lumen
GO:0034993	SUN-KASH complex
GO:0045111	intermediate filament cytoskeleton