Version 5.4
Bos taurus Gene: PURB
Summary
InnateDB Gene IDBG-647013.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PURB
Gene Name transcriptional activator protein Pur-beta
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000046625
Encoded Proteins
IDBP-699867
purine-rich element binding protein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146676:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:77365884-77366798
Strand Forward strand
Band
Transcripts
ENSBTAT00000063608 ENSBTAP00000055488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
GO:0046332 SMAD binding
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146676
View Gene Order
ENSMUSG00000094483
View Gene Order
Cross-References
SwissProt
TrEMBL G3N0W8
UniProt Splice Variant
Entrez Gene 504276
UniGene Bt.28754
RefSeq NM_001206632
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02011179
GenPept
RNA Seq Atlas 504276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca