Version 5.4
Bos taurus Gene: AKAP12
Summary
InnateDB Gene IDBG-647058.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP12
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014788
Encoded Proteins
IDBP-699907
A kinase (PRKA) anchor protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131016:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89558649-89563595
Strand Forward strand
Band
Transcripts
ENSBTAT00000019669 ENSBTAP00000053994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0010739 positive regulation of protein kinase A signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0090036 regulation of protein kinase C signaling
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131016
View Gene Order
ENSMUSG00000038587
View Gene Order
Cross-References
SwissProt
TrEMBL G3MWT9
UniProt Splice Variant
Entrez Gene 513774
UniGene Bt.110087
RefSeq XM_002690338 XM_005199435 XM_005199436 XM_005199437 XM_005199438 XM_005211057 XM_005211058 XM_005211059 XM_591518
HUGO HGNC:370
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027168
GenPept
RNA Seq Atlas 513774

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca