InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.106551

Summary

InnateDB Gene

IDBG-647064.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.106551

Gene Name

C-C chemokine receptor type 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014496

Encoded Proteins

IDBP-699913

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21042003

[Homo sapiens] CCR6 mobilizes TCR-alpha/beta+, CCR6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. CCR6 is not required for induction of the adaptive antimycobacterial response

PMID 21376174

[Homo sapiens] CCR6 is a chemokine receptor that only binds to a single chemokine ligand, CCL20. CCR6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.

PMID 21042003

[Mus musculus] Ccr6 mobilizes TCR-alpha/beta+, Ccr6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. Ccr6 is not required for induction of the adaptive antimycobacterial response

PMID 21376174

[Mus musculus] Ccr6 is a chemokine receptor that only binds to a single chemokine ligand, Ccl20. Ccr6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112486:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:103460841-103461953

Strand

Forward strand

Band

Transcripts

ENSBTAT00000037034

ENSBTAP00000036877

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway