Version 5.4
Bos taurus Gene: NFIL3
Summary
InnateDB Gene IDBG-647479.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIL3
Gene Name Nuclear factor interleukin-3-regulated protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017763
Encoded Proteins
IDBP-700301
Nuclear factor interleukin-3-regulated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19749763
[Homo sapiens] NFIL3 is essential for generation of the natural killer (NK) cell lineage.
PMID 21383239
[Homo sapiens] NFIL3 is an IL12B transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce NFIL3 to limit their inflammatory capacity. (Demonstrated in murine model)
PMID 21383239
[Mus musculus] Nfil3 is an Il12b transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce Nfil3 to limit their inflammatory capacity.
PMID 25801035
[Mus musculus] Nfil3 is a key regulator of common helper-like innate lymphoid cell progenitors as they emerge during early lymphopoiesis.
Entrez Gene
Summary The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:87891326-87893182
Strand Forward strand
Band
Transcripts
ENSBTAT00000023618 ENSBTAP00000023618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007623 circadian rhythm
GO:0010628 positive regulation of gene expression
GO:0048511 rhythmic process
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165030
View Gene Order
ENSMUSG00000056749
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.27854 Bt.90308
RefSeq NM_001075240 XM_005210420 XM_005210421 XM_005210422 XM_005210423 XM_005210424 XM_005210425
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca