InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfil3

Summary

InnateDB Gene

IDBG-152923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfil3

Gene Name

nuclear factor, interleukin 3, regulated

Synonyms

AV225605; E4BP4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056749

Encoded Proteins

IDBP-152925

nuclear factor, interleukin 3, regulated

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21383239

Nfil3 is an Il12b transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce Nfil3 to limit their inflammatory capacity.

PMID 25801035

Nfil3 is a key regulator of common helper-like innate lymphoid cell progenitors as they emerge during early lymphopoiesis.

InnateDB Annotation from Orthologs

Summary

PMID 19749763

[Homo sapiens] NFIL3 is essential for generation of the natural killer (NK) cell lineage.

PMID 21383239

[Homo sapiens] NFIL3 is an IL12B transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce NFIL3 to limit their inflammatory capacity. (Demonstrated in murine model)

Entrez Gene

Summary

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:52967209-52981073

Strand

Reverse strand

Band

Transcripts

ENSMUST00000071065

ENSMUSP00000065363

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	2 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007623	circadian rhythm
GO:0010628	positive regulation of gene expression
GO:0045087	innate immune response (InnateDB)
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165030

View Gene Order

ENSBTAG00000017763

Not yet available

Cross-References

SwissProt

O08750

TrEMBL

UniProt Splice Variant

Entrez Gene

18030

UniGene

Mm.136604

RefSeq

NM_017373 XM_006516875 XM_006516876 XM_006516877 XM_006516878 XM_006516879

OMIM

CCDS

CCDS26519

HPRD

IMGT

MGI ID

MGI:109495

MGI Symbol

Nfil3

EMBL

AK145451 AY061760 BC031377 BC100384 U83148

GenPept

AAB53973 AAH31377 AAI00385 AAL29942 BAE26446

RNA Seq Atlas

18030