Version 5.4
Homo sapiens Gene: NFIL3
Summary
InnateDB Gene IDBG-75722.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIL3
Gene Name nuclear factor, interleukin 3 regulated
Synonyms E4BP4; IL3BP1; NF-IL3A; NFIL3A
Species Homo sapiens
Ensembl Gene ENSG00000165030
Encoded Proteins
IDBP-75726
nuclear factor, interleukin 3 regulated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19749763
NFIL3 is essential for generation of the natural killer (NK) cell lineage.
PMID 21383239
NFIL3 is an IL12B transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce NFIL3 to limit their inflammatory capacity. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21383239
[Mus musculus] Nfil3 is an Il12b transcriptional inhibitor in macrophages. Interactions of macrophages with the enteric microbiota induce Nfil3 to limit their inflammatory capacity.
PMID 25801035
[Mus musculus] Nfil3 is a key regulator of common helper-like innate lymphoid cell progenitors as they emerge during early lymphopoiesis.
Entrez Gene
Summary Expression of interleukin-3 (IL3; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995 [PubMed 7565758]).[supplied by OMIM, Feb 2009]
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:91409045-91423862
Strand Reverse strand
Band q22.31
Transcripts
ENST00000297689 ENSP00000297689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007623 circadian rhythm
GO:0010628 positive regulation of gene expression
GO:0045087 innate immune response (InnateDB)
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056749
View Gene Order
ENSBTAG00000017763
Not yet available
Cross-References
SwissProt Q16649
TrEMBL A0A024R241
UniProt Splice Variant
Entrez Gene 4783
UniGene Hs.599756 Hs.602328 Hs.79334
RefSeq NM_001289999 NM_001290000 NM_005384 XM_005251999 XM_005252000
HUGO HGNC:7787
OMIM 605327
CCDS CCDS6690
HPRD
IMGT
EMBL AK313970 AL353764 BC008197 CH471089 CR542049 EF028070 S79880 U26173 X64318
GenPept AAA93067 AAB35410 AAH08197 ABK15691 BAG36685 CAA45597 CAG46846 CAH73854 EAW62796 EAW62797
RNA Seq Atlas 4783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca