Bos taurus Gene: SOCS3
Summary
InnateDB Gene IDBG-647946.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS3
Gene Name Suppressor of cytokine signaling 3
Synonyms SSI-3
Species Bos taurus
Ensembl Gene ENSBTAG00000008441
Encoded Proteins
Suppressor of cytokine signaling 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SOCS3 inhibits the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis (EPO) by binding the JAK2 and EPO receptor, respectively.
[Homo sapiens] SOCS3 is rapidly induced by IL-2 in T cells where it acts to inhibit IL-2 responses in a classical negative feedback loop by suppressing STAT5 phosphorylation and lymphocyte proliferation.
[Homo sapiens] SOCS3 protein is a potent endogenous inhibitor of Janus kinase (JAK)/STAT signalling and influenza A virus inhibits type I IFN signalling via NF-kappaB-dependent induction of SOCS3 expression.
[Homo sapiens] SOCS3 is a molecular inhibitor of IFN signalling and SOCS3 expression, induced by stimuli present in the Human immunodeficiency virus (HIV)-1-infected brain, such as transactivator of transcription, inhibits antiviral IFN-beta signalling to enhance HIV-1 replication in macrophages, allowing HIV-1 to evade the protective innate immune response within the central nervous system.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184557:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54458856-54459555
Strand Forward strand
Band
Transcripts
ENSBTAT00000011106 ENSBTAP00000011106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0043066 negative regulation of apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Regulation of IFNA signaling pathway
Signaling by Leptin pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon gamma signaling pathway
Immune System pathway
Signal Transduction pathway
Interleukin-6 signaling pathway
Interferon Signaling pathway
Growth hormone receptor signaling pathway
Regulation of IFNG signaling pathway
Signaling by Interleukins pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
Leptin pathway
TSH pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Growth hormone receptor signaling pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interleukin-6 signaling pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by Leptin pathway
Mus musculus biological processes pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by Leptin pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Signaling by Interleukins pathway
Interleukin-6 signaling pathway
Adaptive Immune System pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
Signaling by Leptin pathway
Interferon alpha/beta signaling pathway
KEGG
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Adipocytokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
Ubiquitin mediated proteolysis pathway
Type II diabetes mellitus pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
INOH
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
PID NCI
IL2-mediated signaling events
Signaling events mediated by PTP1B
ATF-2 transcription factor network
EPO signaling pathway
IL23-mediated signaling events
IL4-mediated signaling events
IL6-mediated signaling events
Cross-References
SwissProt Q9BEG9
TrEMBL
UniProt Splice Variant
Entrez Gene 282081
UniGene Bt.8137
RefSeq NM_174466 XM_005221139
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY026859
GenPept AAK07689
RNA Seq Atlas 282081