InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAG1

Summary

InnateDB Gene

IDBG-648145.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAG1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000040293

Encoded Proteins

IDBP-700912

recombination activating gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21746813

[Homo sapiens] Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response. (Demonstrated in mice)

PMID 21746813

[Mus musculus] Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166349:
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:67827233-67830364

Strand

Forward strand

Band

Transcripts

ENSBTAT00000055549

ENSBTAP00000048319

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004519	endonuclease activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016881	acid-amino acid ligase activity
GO:0042393	histone binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0002250	adaptive immune response
GO:0002331	pre-B cell allelic exclusion
GO:0010390	histone monoubiquitination
GO:0016265	death
GO:0030183	B cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0043029	T cell homeostasis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045580	regulation of T cell differentiation
GO:0048538	thymus development
GO:0051865	protein autoubiquitination
GO:0070233	negative regulation of T cell apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000166349

View Gene Order

ENSMUSG00000061311

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

mmu05340

Primary immunodeficiency pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MG60

UniProt Splice Variant

Entrez Gene

506302

UniGene

RefSeq

XM_002693521 XM_005194689 XM_005216399 XM_867321

HUGO

HGNC:9831

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02041329

GenPept

RNA Seq Atlas

506302