Version 5.4
| Bos taurus Gene: TLR5 | |||||||||||||||||||||
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| Summary | |||||||||||||||||||||
| InnateDB Gene | IDBG-648348.3 | ||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
| Gene Symbol | TLR5 | ||||||||||||||||||||
| Gene Name | toll-like receptor 5 precursor | ||||||||||||||||||||
| Synonyms | TLR-5 | ||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000000477 | ||||||||||||||||||||
| Encoded Proteins |
toll-like receptor 5
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| Protein Structure | |||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||
| Summary |
[Homo sapiens] TLR5 engagement with its ligand, flagellin, results in the activation of MAP kinases (ERK1/2, JNK, and p38) and degradation of NFKBIA (I-kappa-B-alpha).
[Homo sapiens] Toll-like receptor 5 (TLR5) is the TLR activated by bacterial flagellin and TLR5 residue 268 is responsible for human and mouse discrimination between flagellin molecules.
[Homo sapiens] TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and its activation mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha (TNF) production.
[Homo sapiens] TLR5 expressed on the basolateral surface of intestinal epithelia mediates innate immune inflammatory responses to Salmonella by inducing epithelial pro-inflammatory gene expression.
[Homo sapiens] TLR5 forms heteromeric complexes with TLR4 as well as homomeric complexes. Signaling via heteromeric TLR5/TLR4 complexes is involved in the induction of macrophage nitric oxide (NO) production by Gram-negative flagellin.
[Homo sapiens] TLR5 forms a dimer upon binding to bacterial flagellin.
[Homo sapiens] TLR5 is highly expressed in mucosal dendritic cells and TLR5 signalling restricts regulatory T cell generation. (Demonstrated in mice)
[Homo sapiens] TLR5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation. (Demonstrated in mouse)
[Homo sapiens] CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with TLR5 expression.
[Mus musculus] Tlr5 forms a dimer upon binding to bacterial flagellin. (Demonstrated in human)
[Mus musculus] Tlr5 is highly expressed in mucosal dendritic cells and Tlr5 signalling restricts regulatory T cell generation.
[Mus musculus] Tlr5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation.
[Mus musculus] Flagellin-specific IgG1 antibody response is induced through a Tlr5-, inflammasome-, and Myd88-independent pathway.
[Mus musculus] Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
[Mus musculus] Indirect Tlr5-dependent stimulation of airway conventional dendritic cells is essential to flagellin's mucosal adjuvant activity.
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| Entrez Gene | |||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187554:
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] |
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| Gene Information | |||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||
| Genomic Location | Chromosome 16:27303741-27306317 | ||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||
| Band | |||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
| NETPATH | |||||||||||||||||||||
| REACTOME |
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Toll-like receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||
| PID NCI | |||||||||||||||||||||
| Cross-References | |||||||||||||||||||||
| SwissProt | |||||||||||||||||||||
| TrEMBL | M1H1A6 Q2LDA0 Q4TU54 Q56GY5 | ||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||
| Entrez Gene | 444870 | ||||||||||||||||||||
| UniGene | Bt.66307 | ||||||||||||||||||||
| RefSeq | NM_001040501 | ||||||||||||||||||||
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| CCDS | |||||||||||||||||||||
| HPRD | |||||||||||||||||||||
| IMGT | |||||||||||||||||||||
| EMBL | AY957626 DAAA02042627 DQ058824 DQ335128 EU006637 EU006638 EU006639 EU006640 JQ805125 JQ805126 JQ805127 JQ805128 JQ805129 JQ805130 JQ805131 JQ805132 JQ805133 JQ805134 JQ805136 JQ805137 KC127664 | ||||||||||||||||||||
| GenPept | AAX56983 AAY58240 ABC68311 ABU86926 ABU86927 ABU86928 ABU86929 AFR42387 AFR42388 AFR42389 AFR42390 AFR42391 AFR42392 AFR42393 AFR42394 AFR42395 AFR42396 AFR42398 AFR42399 AGE44306 | ||||||||||||||||||||
| RNA Seq Atlas | 444870 | ||||||||||||||||||||