InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC5A7

Summary

InnateDB Gene

IDBG-64864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC5A7

Gene Name

solute carrier family 5 (choline transporter), member 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115665

Encoded Proteins

IDBP-64866

solute carrier family 5 (choline transporter), member 7

IDBP-294984

solute carrier family 5 (choline transporter), member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:107986523-108013994

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000264047	ENSP00000264047
ENST00000409059	ENSP00000387346

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005307	choline:sodium symporter activity
GO:0005515	protein binding
GO:0015220	choline transmembrane transporter activity
GO:0033265	choline binding

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007271	synaptic transmission, cholinergic
GO:0007274	neuromuscular synaptic transmission
GO:0008219	cell death
GO:0008292	acetylcholine biosynthetic process
GO:0015871	choline transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023945

View Gene Order

ENSBTAG00000004352

Not yet available

Pathways

NETPATH

REACTOME

REACT_19305

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway

REACT_15309

Acetylcholine Neurotransmitter Release Cycle pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9GZV3

TrEMBL

F5H382 Q2T9H3

UniProt Splice Variant

Entrez Gene

60482

UniGene

Hs.287758

RefSeq

NM_021815

HUGO

HGNC:14025

OMIM

608761

CCDS

CCDS2074

HPRD

IMGT

EMBL

AB043997 AC009963 AF276871 AJ308378 AJ308379 AJ308380 AJ308381 AJ308382 AJ308383 AJ308384 AJ401466 BC111524 BC111525

GenPept

AAG25940 AAI11525 AAI11526 AAY14927 BAB18161 CAC03717 CAC88115

RNA Seq Atlas

60482