InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRMT6

Summary

InnateDB Gene

IDBG-648902.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT6

Gene Name

Protein arginine N-methyltransferase 6

Synonyms

HRMT1L6

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039951

Encoded Proteins

IDBP-701607

Protein arginine N-methyltransferase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198890:
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:36428458-36429816

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009750

ENSBTAP00000009750

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042393	histone binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0070611	histone methyltransferase activity (H3-R2 specific)
GO:0070612	histone methyltransferase activity (H2A-R3 specific)

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0006974	cellular response to DNA damage stimulus
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032259	methylation
GO:0034969	histone arginine methylation
GO:0034970	histone H3-R2 methylation
GO:0043985	histone H4-R3 methylation
GO:0045892	negative regulation of transcription, DNA-templated