InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EHHADH

Summary

InnateDB Gene

IDBG-68450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHHADH

Gene Name

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

Synonyms

ECHD; FRTS3; L-PBE; LBFP; LBP; PBFE

Species

Homo sapiens

Ensembl Gene

ENSG00000113790

Encoded Proteins

IDBP-68452

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

IDBP-386234

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

IDBP-386236

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:185190624-185281990

Strand

Reverse strand

Band

q27.2

Transcripts

ENST00000231887	ENSP00000231887
ENST00000456310	ENSP00000387746
ENST00000440662	ENSP00000396798
ENST00000483104
ENST00000475987
ENST00000465178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0004165	dodecenoyl-CoA delta-isomerase activity
GO:0004300	enoyl-CoA hydratase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0050662	coenzyme binding

Biological Process

GO:0006475	internal protein amino acid acetylation
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022853

View Gene Order

ENSBTAG00000019625

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00280

Valine, leucine and isoleucine degradation pathway

hsa00650

Butanoate metabolism pathway

hsa00640

Propanoate metabolism pathway

hsa00380

Tryptophan metabolism pathway

hsa00071

Fatty acid degradation pathway

hsa00310

Lysine degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa00410

beta-Alanine metabolism pathway

hsa04146

Peroxisome pathway

INOH

INOH website

Tryptophan degradation pathway

INOH website

Propanoate metabolism pathway

INOH website

Butanoate metabolism pathway

INOH website

Valine Leucine Isoleucine degradation pathway

INOH website

Lysine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.429879

RefSeq

NM_001166415 NM_001966

HUGO

OMIM

CCDS

CCDS33901 CCDS54694

HPRD

06125

IMGT

EMBL

GenPept

RNA Seq Atlas