InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ehhadh

Summary

InnateDB Gene

IDBG-147437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehhadh

Gene Name

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

Synonyms

1300002P22Rik; HD; L-PBE; LBFP; LBP; MFP; MFP1; PBFE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022853

Encoded Proteins

IDBP-147439

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113790:
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:21761287-21787844

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023559

ENSMUSP00000023559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0004165	dodecenoyl-CoA delta-isomerase activity
GO:0004300	enoyl-CoA hydratase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0050662	coenzyme binding

Biological Process

GO:0006475	internal protein amino acid acetylation
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process