Version 5.4
Homo sapiens Gene: SESN3
Summary
InnateDB Gene IDBG-68476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SESN3
Gene Name sestrin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149212
Encoded Proteins
IDBP-68478
sestrin 3
IDBP-382281
sestrin 3
IDBP-599095
sestrin 3
IDBP-585578
sestrin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:95165540-95232541
Strand Reverse strand
Band q21
Transcripts
ENST00000278499 ENSP00000278499
ENST00000416495 ENSP00000407008
ENST00000536441 ENSP00000441927
ENST00000542176 ENSP00000439580
ENST00000537480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0032868 response to insulin
GO:0042593 glucose homeostasis
GO:0051896 regulation of protein kinase B signaling
GO:1901031 regulation of response to reactive oxygen species
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032009
View Gene Order
ENSBTAG00000004034
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.120633 Hs.487845 Hs.599489 Hs.624745 Hs.659934 Hs.711545 Hs.739684
RefSeq NM_001271594 NM_144665
HUGO
OMIM
CCDS CCDS60938 CCDS8303
HPRD 09682
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca