InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: U2AF2

Summary

InnateDB Gene

IDBG-71019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2AF2

Gene Name

U2 small nuclear RNA auxiliary factor 2

Synonyms

U2AF65

Species

Homo sapiens

Ensembl Gene

ENSG00000063244

Encoded Proteins

IDBP-71023

U2 small nuclear RNA auxiliary factor 2

IDBP-385467

U2 small nuclear RNA auxiliary factor 2

IDBP-766292

IDBP-760728

IDBP-760619

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:55654146-55674715

Strand

Forward strand

Band

q13.42

Transcripts

ENST00000308924	ENSP00000307863
ENST00000450554	ENSP00000388475
ENST00000592874	ENSP00000466167
ENST00000592867
ENST00000590551	ENSP00000466935
ENST00000588850
ENST00000587196	ENSP00000470020
ENST00000587275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 183 experimentally validated interaction(s) in this database.

Experimentally validated
Total	183 [view]
Protein-Protein	182 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome