Version 5.4
Homo sapiens Gene: CXCR4
Summary
InnateDB Gene IDBG-71032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCR4
Gene Name chemokine (C-X-C motif) receptor 4
Synonyms CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM
Species Homo sapiens
Ensembl Gene ENSG00000121966
Encoded Proteins
IDBP-71034
chemokine (C-X-C motif) receptor 4
IDBP-294150
chemokine (C-X-C motif) receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21094463
CXCR4 is a chemokine receptor that is essential for homing of stem cells and more mature neutrophils to the bone marrow.
PMID 25705792
MIR146A upregulation by CXCR4 antagonist AMD3100 treatment or ZBTB16 silencing, decreases CXCR4 protein expression and prevents HIV-1 infection of leukemic monocytic cell line and CD4(+) T lymphocytes.
InnateDB Annotation from Orthologs
Summary
PMID 26026270
[Mus musculus] Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.
Entrez Gene
Summary This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:136114349-136118165
Strand Reverse strand
Band q22.1
Transcripts
ENST00000241393 ENSP00000241393
ENST00000409817 ENSP00000386884
ENST00000466288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 61 [view]
Protein-DNA 22 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003779 actin binding
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019955 cytokine binding
GO:0031625 ubiquitin protein ligase binding
GO:0032027 myosin light chain binding
GO:0043130 ubiquitin binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001667 ameboidal cell migration
GO:0001764 neuron migration
GO:0002407 dendritic cell chemotaxis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007281 germ cell development
GO:0007420 brain development
GO:0008045 motor neuron axon guidance
GO:0008354 germ cell migration
GO:0009615 response to virus
GO:0016032 viral process
GO:0019722 calcium-mediated signaling
GO:0030260 entry into host cell
GO:0030334 regulation of cell migration
GO:0042098 T cell proliferation
GO:0042119 neutrophil activation
GO:0043217 myelin maintenance
GO:0045087 innate immune response (InnateDB)
GO:0048699 generation of neurons
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050920 regulation of chemotaxis
GO:0061351 neural precursor cell proliferation
GO:0070098 chemokine-mediated signaling pathway
GO:0071345 cellular response to cytokine stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0030426 growth cone
GO:0031252 cell leading edge
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045382
View Gene Order
ENSBTAG00000001060
Not yet available
Pathways
NETPATH
NetPath_16
IL4 pathway
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_6903
Binding and entry of HIV virion pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_21340
GPCR ligand binding pathway
REACT_116125
Disease pathway
KEGG
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
s1p_s1p3_pathway
S1P3 pathway
hif1_tfpathway
HIF-1-alpha transcription factor network
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt P61073
TrEMBL Q5MIL4
UniProt Splice Variant
Entrez Gene 7852
UniGene Hs.593413
RefSeq NM_001008540 NM_003467
HUGO HGNC:2561
OMIM 162643
CCDS CCDS33295 CCDS46420
HPRD 01217
IMGT
EMBL AC068492 AF005058 AF025375 AF052572 AF147204 AF348491 AJ224869 AK312244 AY242129 AY728138 AY826773 BC020968 BT006660 CH471058 D10924 L01639 L06797 M99293 X71635 Y14739
GenPept AAA03209 AAA16594 AAA16617 AAB81970 AAB93982 AAC34581 AAF00130 AAH20968 AAK29630 AAO92296 AAP35306 AAU05775 AAV97584 AAY24044 BAA01722 BAG35177 CAA12166 CAA50641 CAA75034 EAX11616
RNA Seq Atlas 7852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca