Version 5.4
Homo sapiens Gene: FN3KRP
Summary
InnateDB Gene IDBG-73747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FN3KRP
Gene Name fructosamine 3 kinase related protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141560
Encoded Proteins
IDBP-73749
fructosamine 3 kinase related protein
IDBP-762849
IDBP-760563
IDBP-760513
IDBP-764789
IDBP-763472
IDBP-764426
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82716683-82730328
Strand Forward strand
Band q25.3
Transcripts
ENST00000269373 ENSP00000269373
ENST00000574356 ENSP00000458550
ENST00000574206 ENSP00000460777
ENST00000571482
ENST00000571594 ENSP00000459751
ENST00000577128 ENSP00000459653
ENST00000576363
ENST00000574832 ENSP00000460869
ENST00000573158 ENSP00000460243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0008152 metabolic process
GO:0016310 phosphorylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039253
View Gene Order
ENSBTAG00000015390
Not yet available
Cross-References
SwissProt
TrEMBL I3L378
UniProt Splice Variant
Entrez Gene 79672
UniGene
RefSeq NM_024619
HUGO HGNC:25700
OMIM 611683
CCDS CCDS11817
HPRD 13546
IMGT
EMBL AC024361
GenPept
RNA Seq Atlas 79672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca