Version 5.4
Homo sapiens Gene: KIF27
Summary
InnateDB Gene IDBG-73799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF27
Gene Name kinesin family member 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165115
Encoded Proteins
IDBP-73801
kinesin family member 27
IDBP-73803
kinesin family member 27
IDBP-73805
kinesin family member 27
IDBP-374108
kinesin family member 27
IDBP-589721
kinesin family member 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:83836698-83921465
Strand Reverse strand
Band q21.32
Transcripts
ENST00000297814 ENSP00000297814
ENST00000334204 ENSP00000333928
ENST00000376347 ENSP00000365525
ENST00000413982 ENSP00000401688
ENST00000495062 ENSP00000431390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0003351 epithelial cilium movement
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
GO:0021591 ventricular system development
GO:0042384 cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060176
View Gene Order
ENSBTAG00000020436
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z355
UniProt Splice Variant
Entrez Gene 55582
UniGene Hs.697514
RefSeq NM_001271927 NM_001271928 NM_017576 XM_005252091 XM_005252092 XM_006717176 XM_006717177 XM_006717178
HUGO HGNC:18632
OMIM 611253
CCDS CCDS65071 CCDS65072 CCDS6665
HPRD 11179
IMGT
EMBL AL354733
GenPept
RNA Seq Atlas 55582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca