Version 5.4
Homo sapiens Gene: TET1
Summary
InnateDB Gene IDBG-76143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TET1
Gene Name tet methylcytosine dioxygenase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138336
Encoded Proteins
IDBP-76145
tet methylcytosine dioxygenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68560656-68694482
Strand Forward strand
Band q21.3
Transcripts
ENST00000373644 ENSP00000362748
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005506 iron ion binding
GO:0008270 zinc ion binding
GO:0043566 structure-specific DNA binding
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0001826 inner cell mass cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006493 protein O-linked glycosylation
GO:0016568 chromatin modification
GO:0019827 stem cell maintenance
GO:0044030 regulation of DNA methylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055114 oxidation-reduction process
GO:0080111 DNA demethylation
GO:0090310 negative regulation of methylation-dependent chromatin silencing
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047146
View Gene Order
ENSBTAG00000037756
Not yet available
Pathways
NETPATH
REACTOME
REACT_200682
TET1,2,3 and TDG demethylate DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8NFU7
TrEMBL
UniProt Splice Variant
Entrez Gene 80312
UniGene Hs.567594 Hs.708977
RefSeq NM_030625
HUGO HGNC:29484
OMIM 607790
CCDS CCDS7281
HPRD 09694
IMGT
EMBL AB051463 AF430147 AL513534 AL713658 AL713888 BC053905
GenPept AAH53905 AAM88301 BAB21767 CAD28467 CAH70220 CAI15118
RNA Seq Atlas 80312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca