Version 5.4
Homo sapiens Gene: JAM3
Summary
InnateDB Gene IDBG-76413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAM3
Gene Name junctional adhesion molecule 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166086
Encoded Proteins
IDBP-76415
junctional adhesion molecule 3
IDBP-384796
junctional adhesion molecule 3
IDBP-597142
junctional adhesion molecule 3
IDBP-594810
junctional adhesion molecule 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21706006
JAM3 is a key regulator of polarized neutrophil transendothelial migration in vivo. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21706006
[Mus musculus] Jam3 is a key regulator of polarized neutrophil transendothelial migration in vivo.
Entrez Gene
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:134068925-134152001
Strand Forward strand
Band q25
Transcripts
ENST00000299106 ENSP00000299106
ENST00000441717 ENSP00000395742
ENST00000532252 ENSP00000432455
ENST00000534549 ENSP00000433206
ENST00000531302
ENST00000524969
ENST00000532165
ENST00000533711
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0001780 neutrophil homeostasis
GO:0002250 adaptive immune response
GO:0002318 myeloid progenitor cell differentiation
GO:0002523 leukocyte migration involved in inflammatory response
GO:0007160 cell-matrix adhesion
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007596 blood coagulation
GO:0016477 cell migration
GO:0019226 transmission of nerve impulse
GO:0030010 establishment of cell polarity
GO:0030198 extracellular matrix organization
GO:0031103 axon regeneration
GO:0042552 myelination
GO:0045087 innate immune response (InnateDB)
GO:0050900 leukocyte migration
GO:0090022 regulation of neutrophil chemotaxis
GO:0090138 regulation of actin cytoskeleton organization by cell-cell adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0030057 desmosome
GO:0033010 paranodal junction
GO:0043220 Schmidt-Lanterman incisure
GO:0044291 cell-cell contact zone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031990
View Gene Order
ENSBTAG00000003176
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.150718 Hs.728339 Hs.733444
RefSeq NM_001205329 NM_032801
HUGO
OMIM
CCDS CCDS55799 CCDS8494
HPRD 06042
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca