Version 5.4
Homo sapiens Gene: UPRT
Summary
InnateDB Gene IDBG-77377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPRT
Gene Name uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000094841
Encoded Proteins
IDBP-77379
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
IDBP-77381
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
IDBP-77383
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
IDBP-590514
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
IDBP-598108
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:75274085-75304600
Strand Forward strand
Band q13.3
Transcripts
ENST00000373383 ENSP00000362481
ENST00000373379 ENSP00000362477
ENST00000373373 ENSP00000362471
ENST00000462237 ENSP00000433987
ENST00000474175
ENST00000531704
ENST00000530743 ENSP00000434037
ENST00000526850
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0009116 nucleoside metabolic process
GO:0032868 response to insulin
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073016
View Gene Order
ENSBTAG00000004549
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.608732 Hs.614532
RefSeq NM_145052 XM_006724620
HUGO
OMIM
CCDS CCDS14429
HPRD 06640
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca