InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPAR1

Summary

InnateDB Gene

IDBG-80609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPAR1

Gene Name

lysophosphatidic acid receptor 1

Synonyms

edg-2; EDG2; Gpcr26; GPR26; LPA1; Mrec1.3; rec.1.3; vzg-1; VZG1

Species

Homo sapiens

Ensembl Gene

ENSG00000198121

Encoded Proteins

IDBP-80611

lysophosphatidic acid receptor 1

IDBP-80613

lysophosphatidic acid receptor 1

IDBP-80615

lysophosphatidic acid receptor 1

IDBP-377730

lysophosphatidic acid receptor 1

IDBP-595877

lysophosphatidic acid receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:110873263-111038458

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000374431	ENSP00000363553
ENST00000374430	ENSP00000363552
ENST00000358883	ENSP00000351755
ENST00000441240	ENSP00000401810
ENST00000541779	ENSP00000445697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0010942	positive regulation of cell death
GO:0010977	negative regulation of neuron projection development
GO:0022008	neurogenesis
GO:0032060	bleb assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0042552	myelination
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0071453	cellular response to oxygen levels
GO:0071673	positive regulation of smooth muscle cell chemotaxis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft