InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LPAR1

Summary

InnateDB Gene

IDBG-637833.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPAR1

Gene Name

lysophosphatidic acid receptor 1

Synonyms

EDG2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009654

Encoded Proteins

IDBP-689868

lysophosphatidic acid receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198121:
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:102051154-102141484

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012721

ENSBTAP00000012721

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0070915	lysophosphatidic acid receptor activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032060	bleb assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade