InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LDB3

Summary

InnateDB Gene

IDBG-80995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDB3

Gene Name

LIM domain binding 3

Synonyms

CMD1C; CMPD3; CYPHER; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP

Species

Homo sapiens

Ensembl Gene

ENSG00000122367

Encoded Proteins

IDBP-80999

LIM domain binding 3

IDBP-81001

LIM domain binding 3

IDBP-81005

LIM domain binding 3

IDBP-81011

LIM domain binding 3

IDBP-381749

LIM domain binding 3

IDBP-812625

LIM domain binding 3

IDBP-603388

LIM domain binding 3

IDBP-812620

LIM domain binding 3

IDBP-812624

LIM domain binding 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:86668449-86736068

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000372066	ENSP00000361136
ENST00000361373	ENSP00000355296
ENST00000263066	ENSP00000263066
ENST00000372056	ENSP00000361126
ENST00000429277	ENSP00000401437
ENST00000477489	ENSP00000485538
ENST00000542786	ENSP00000438866
ENST00000623056	ENSP00000485500
ENST00000623007	ENSP00000485389

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008270	zinc ion binding
GO:0051371	muscle alpha-actinin binding

Biological Process

GO:0045214

sarcomere organization

Cellular Component

GO:0005856	cytoskeleton
GO:0030018	Z disc
GO:0031143	pseudopodium
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021798

View Gene Order

ENSBTAG00000018707

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001080114 NM_001080115 NM_001080116 NM_001171610 NM_001171611 NM_007078 XM_005269464 XM_005269468 XM_006717598 XM_006717600 XM_006717601

HUGO

OMIM

CCDS

CCDS41544 CCDS41545 CCDS53549 CCDS53550 CCDS7377

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas