InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MC3R

Summary

InnateDB Gene

IDBG-81747.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC3R

Gene Name

melanocortin 3 receptor

Synonyms

BMIQ9; MC3; MC3-R; OB20; OQTL

Species

Homo sapiens

Ensembl Gene

ENSG00000124089

Encoded Proteins

IDBP-81749

melanocortin 3 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:56248732-56249815

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000243911

ENSP00000243911

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0002027	regulation of heart rate
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0042309	homoiothermy
GO:0055078	sodium ion homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038537

View Gene Order

ENSBTAG00000004712

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P41968

TrEMBL

UniProt Splice Variant

Entrez Gene

4159

UniGene

Hs.248018

RefSeq

NM_019888

HUGO

HGNC:6931

OMIM

155540

CCDS

CCDS13449

HPRD

IMGT

EMBL

AL139824 AY227893 BC069105 BC069599 BC096702 BC096737 BC098169 BC098351 L06155

GenPept

AAC13541 AAH69105 AAH69599 AAH96702 AAH96737 AAH98169 AAH98351 AAO72726 CAC15480

RNA Seq Atlas

4159