Version 5.4
Homo sapiens Gene: SLC2A8
Summary
InnateDB Gene IDBG-85761.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC2A8
Gene Name solute carrier family 2 (facilitated glucose transporter), member 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136856
Encoded Proteins
IDBP-85763
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-85765
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-85771
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380777
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380782
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380794
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380798
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380799
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-380801
solute carrier family 2 (facilitated glucose transporter), member 8
IDBP-809219
solute carrier family 2 (facilitated glucose transporter), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127397138-127408424
Strand Forward strand
Band q33.3
Transcripts
ENST00000373371 ENSP00000362469
ENST00000373360 ENSP00000362458
ENST00000373352 ENSP00000362450
ENST00000451404 ENSP00000392434
ENST00000419917 ENSP00000411726
ENST00000419132 ENSP00000413973
ENST00000423934 ENSP00000389070
ENST00000439597 ENSP00000404893
ENST00000430147 ENSP00000391213
ENST00000484617
ENST00000489239
ENST00000477027
ENST00000485806
ENST00000484208
ENST00000610552 ENSP00000477568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0005536 glucose binding
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
Biological Process
GO:0001666 response to hypoxia
GO:0005975 carbohydrate metabolic process
GO:0007141 male meiosis I
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0015758 glucose transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026791
View Gene Order
ENSBTAG00000006957
Not yet available
Pathways
NETPATH
REACTOME
REACT_19343
Facilitative Na+-independent glucose transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NY64
TrEMBL A0A024R871 Q5VVV3 Q5VVV4 Q5VVV5 Q5VVV6 Q5VVV9 Q5VVW0 Q5VVW5 Q8WZ05
UniProt Splice Variant
Entrez Gene 29988
UniGene Hs.179522 Hs.735071
RefSeq NM_001271711 NM_001271712 NM_014580 XM_005251949
HUGO HGNC:13812
OMIM 605245
CCDS CCDS65138 CCDS6870 CCDS75903
HPRD
IMGT
EMBL AF289587 AJ245937 AL445222 BC019043 CH471090 Y17801
GenPept AAH19043 AAL55771 CAB75702 CAB89809 CAH72918 EAW87660 EAW87661 EAW87662 EAW87664
RNA Seq Atlas 29988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca