Version 5.4
Homo sapiens Gene: XPO5
Summary
InnateDB Gene IDBG-88428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPO5
Gene Name exportin 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124571
Encoded Proteins
IDBP-88430
exportin 5
IDBP-232042
exportin 5
IDBP-232044
exportin 5
IDBP-379964
exportin 5
IDBP-474703
exportin 5
IDBP-474138
exportin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43522330-43576075
Strand Reverse strand
Band p21.1
Transcripts
ENST00000265351 ENSP00000265351
ENST00000398835 ENSP00000381816
ENST00000398799 ENSP00000381779
ENST00000424378
ENST00000455285 ENSP00000387384
ENST00000450462
ENST00000455854
ENST00000488195
ENST00000486936 ENSP00000426185
ENST00000513451
ENST00000496341 ENSP00000424196
ENST00000612911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 61 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0010467 gene expression
GO:0031047 gene silencing by RNA
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067150
View Gene Order
ENSBTAG00000018970
Not yet available
Pathways
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.203206
RefSeq NM_020750
HUGO
OMIM
CCDS CCDS47430
HPRD 06385
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca