Version 5.4
Homo sapiens Gene: XPNPEP1
Summary
InnateDB Gene IDBG-88996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPNPEP1
Gene Name X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1
Species Homo sapiens
Ensembl Gene ENSG00000108039
Encoded Proteins
IDBP-88998
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
IDBP-89002
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
IDBP-294391
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
IDBP-385295
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
IDBP-482803
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:109864766-109923553
Strand Reverse strand
Band q25.1
Transcripts
ENST00000369683 ENSP00000358697
ENST00000322238 ENSP00000324011
ENST00000369658
ENST00000403138 ENSP00000385388
ENST00000430337
ENST00000423625 ENSP00000410318
ENST00000443078
ENST00000451592
ENST00000488118
ENST00000502935 ENSP00000421566
ENST00000494499
ENST00000494564
ENST00000510988
ENST00000472336
ENST00000513817
ENST00000508525
ENST00000460055
ENST00000507328
ENST00000512582
ENST00000509646
ENST00000460523
ENST00000508059
ENST00000506777
ENST00000505255
ENST00000490740
ENST00000502595
ENST00000508275
ENST00000475123
ENST00000504664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0010815 bradykinin catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025027
View Gene Order
ENSBTAG00000004438
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001167604 NM_020383 XM_005270144 XM_006717962
HUGO
OMIM
CCDS CCDS53576 CCDS7560
HPRD 03899
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca