Homo sapiens Gene: PLA2G2D

Summary
InnateDB Gene IDBG-92826.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PLA2G2D
Gene Name phospholipase A2, group IID
Synonyms PLA2IID; sPLA2-IID; sPLA2S; SPLASH
Species Homo sapiens
Ensembl Gene ENSG00000117215
Encoded Proteins
IDBP-92828 phospholipase A2, group IID
Entrez Gene
Summary This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 20438432-20446050
Strand Reverse strand
Band p36.12
Transcripts
ENST00000375105  ENSP00000364246
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  0
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006954 inflammatory response
GO:0016042 lipid catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000041202 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000020499 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
hsa00592  Alpha-Linolenic acid metabolism
hsa00590  Arachidonic acid metabolism
hsa00565  Ether lipid metabolism
hsa04975  Fat digestion and absorption
hsa04664  Fc epsilon RI signaling pathway
hsa00564  Glycerophospholipid metabolism
hsa04912  GnRH signaling pathway
hsa00591  Linoleic acid metabolism
hsa04730  Long-term depression
hsa04010  MAPK signaling pathway
hsa01100  Metabolic pathways
hsa04972  Pancreatic secretion
hsa05145  Toxoplasmosis
hsa04370  VEGF signaling pathway
hsa04270  Vascular smooth muscle contraction
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UNK4 
TrEMBL
UniProt Splice Variant
Entrez Gene 26279 
UniGene Hs.189507
RefSeq NM_012400 
HUGO 9033 
OMIM 605630
CCDS CCDS203 
HPRD 07546
IMGT
EMBL AF112982 AF188625 AK290406 AL158172 BC025706 EU447440
GenPept AAD51390  AAF09020  AAH25706  ACA06110  BAF83095  CAC13159 
ImmGen PLA2G2D (murine) 
RNA Seq Atlas 26279