Homo sapiens Gene: PLA2G2D
Summary
InnateDB Gene IDBG-92826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G2D
Gene Name phospholipase A2, group IID
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117215
Encoded Proteins
phospholipase A2, group IID
phospholipase A2, group IID
Protein Structure
Entrez Gene
Summary This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20111939-20119566
Strand Reverse strand
Band p36.12
Transcripts
ENST00000375105 ENSP00000364246
ENST00000617227 ENSP00000482871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006954 inflammatory response
GO:0016042 lipid catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Acyl chain remodelling of PS pathway
Metabolism of lipids and lipoproteins pathway
Acyl chain remodelling of PC pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Metabolism pathway
Acyl chain remodelling of PI pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Arachidonic acid metabolism pathway
Linoleic acid metabolism pathway
alpha-Linolenic acid metabolism pathway
Vascular smooth muscle contraction pathway
Pancreatic secretion pathway
Fat digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UNK4
TrEMBL
UniProt Splice Variant
Entrez Gene 26279
UniGene Hs.189507
RefSeq NM_001271814 NM_012400
HUGO HGNC:9033
OMIM 605630
CCDS CCDS203 CCDS72721
HPRD 07546
IMGT
EMBL AF112982 AF188625 AK290406 AL158172 BC025706 EU447440
GenPept AAD51390 AAF09020 AAH25706 ACA06110 BAF83095 CAC13159
ImmGen PLA2G2D (murine)
RNA Seq Atlas 26279