Version 5.4
Homo sapiens Gene: DNAH11
Summary
InnateDB Gene IDBG-9317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAH11
Gene Name dynein, axonemal, heavy chain 11
Synonyms CILD7; DNAHBL; DNAHC11; DNHBL; DPL11
Species Homo sapiens
Ensembl Gene ENSG00000105877
Encoded Proteins
IDBP-9319
dynein, axonemal, heavy chain 11
IDBP-808181
dynein, axonemal, heavy chain 11
IDBP-808184
dynein, axonemal, heavy chain 11
IDBP-808190
dynein, axonemal, heavy chain 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:21543215-21901839
Strand Forward strand
Band p15.3
Transcripts
ENST00000328843 ENSP00000330671
ENST00000409508 ENSP00000475939
ENST00000421290
ENST00000483691
ENST00000496218
ENST00000465593
ENST00000465129
ENST00000479878
ENST00000607050
ENST00000605912 ENSP00000476068
ENST00000607413
ENST00000620169 ENSP00000481693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0003341 cilium movement
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
GO:0007368 determination of left/right symmetry
GO:0008152 metabolic process
Cellular Component
GO:0005874 microtubule
GO:0030286 dynein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018581
View Gene Order
ENSBTAG00000013078
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741330
RefSeq NM_001277115
HUGO
OMIM
CCDS CCDS64602
HPRD 09134
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca