InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CGA

Summary

InnateDB Gene

IDBG-94098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CGA

Gene Name

glycoprotein hormones, alpha polypeptide

Synonyms

CG-ALPHA; FSHA; GPHa; GPHA1; HCG; LHA; TSHA

Species

Homo sapiens

Ensembl Gene

ENSG00000135346

Encoded Proteins

IDBP-94100

glycoprotein hormones, alpha polypeptide

IDBP-812208

glycoprotein hormones, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:87085498-87095147

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000369582	ENSP00000358595
ENST00000610310	ENSP00000482232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008406	gonad development
GO:0016486	peptide hormone processing
GO:0030335	positive regulation of cell migration
GO:0030878	thyroid gland development
GO:0032275	luteinizing hormone secretion
GO:0032870	cellular response to hormone stimulus
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046621	negative regulation of organ growth
GO:0046884	follicle-stimulating hormone secretion
GO:0048589	developmental growth