InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WASF2

Summary

InnateDB Gene

IDBG-94907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASF2

Gene Name

WAS protein family, member 2

Synonyms

dJ393P12.2; IMD2; SCAR2; WASF4; WAVE2

Species

Homo sapiens

Ensembl Gene

ENSG00000158195

Encoded Proteins

IDBP-600758

WAS protein family, member 2

IDBP-806614

WAS protein family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27404226-27490158

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000536657	ENSP00000439883
ENST00000618852	ENSP00000483313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001525	angiogenesis
GO:0001667	ameboidal cell migration
GO:0006897	endocytosis
GO:0006928	cellular component movement
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0010592	positive regulation of lamellipodium assembly
GO:0016601	Rac protein signal transduction
GO:0030032	lamellipodium assembly
GO:0030036	actin cytoskeleton organization
GO:0030048	actin filament-based movement
GO:0035855	megakaryocyte development
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0051497	negative regulation of stress fiber assembly
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0031209	SCAR complex
GO:0070062	extracellular vesicular exosome