Version 5.4
Homo sapiens Gene: FABP3
Summary
InnateDB Gene IDBG-95442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FABP3
Gene Name fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
Synonyms FABP11; H-FABP; M-FABP; MDGI; O-FABP
Species Homo sapiens
Ensembl Gene ENSG00000121769
Encoded Proteins
IDBP-95444
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
IDBP-812238
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
IDBP-812239
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:31365625-31376850
Strand Reverse strand
Band p35.2
Transcripts
ENST00000373713 ENSP00000362817
ENST00000497275
ENST00000498148 ENSP00000474078
ENST00000482018 ENSP00000473982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005324 long-chain fatty acid transporter activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0036041 long-chain fatty acid binding
GO:0050543 icosatetraenoic acid binding
GO:0070538 oleic acid binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006810 transport
GO:0008285 negative regulation of cell proliferation
GO:0015909 long-chain fatty acid transport
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0044539 long-chain fatty acid import
GO:0046320 regulation of fatty acid oxidation
GO:0055091 phospholipid homeostasis
GO:0070542 response to fatty acid
GO:0071073 positive regulation of phospholipid biosynthetic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016528 sarcoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028773
View Gene Order
ENSBTAG00000016819
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004102
HUGO
OMIM
CCDS CCDS342
HPRD 00613
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca