Version 5.4
Homo sapiens Gene: CAP1
Summary
InnateDB Gene IDBG-96837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAP1
Gene Name CAP, adenylate cyclase-associated protein 1 (yeast)
Synonyms CAP; CAP1-PEN
Species Homo sapiens
Ensembl Gene ENSG00000131236
Encoded Proteins
IDBP-96839
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-96841
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-96843
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-96845
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-96847
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-96851
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381142
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381147
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381149
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381150
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381152
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381155
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381161
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381162
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381166
CAP, adenylate cyclase-associated protein 1 (yeast)
IDBP-381171
CAP, adenylate cyclase-associated protein 1 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40040233-40072649
Strand Forward strand
Band p34.2
Transcripts
ENST00000372805 ENSP00000361891
ENST00000372802 ENSP00000361888
ENST00000372798 ENSP00000361884
ENST00000372797 ENSP00000361883
ENST00000340450 ENSP00000344832
ENST00000372792 ENSP00000361878
ENST00000449311 ENSP00000398475
ENST00000421589 ENSP00000403198
ENST00000414893 ENSP00000398877
ENST00000414281 ENSP00000408561
ENST00000420216 ENSP00000410586
ENST00000435719 ENSP00000412859
ENST00000427843 ENSP00000413656
ENST00000424977 ENSP00000413383
ENST00000417287 ENSP00000400943
ENST00000446031 ENSP00000389974
ENST00000479759
ENST00000461993
ENST00000494114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001667 ameboidal cell migration
GO:0002576 platelet degranulation
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007190 activation of adenylate cyclase activity
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028656
View Gene Order
ENSBTAG00000013363
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_19230
Role of Abl in Robo-Slit signaling pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370581
RefSeq NM_001105530 NM_006367 XM_005270367 XM_005270368 XM_006710294
HUGO
OMIM
CCDS CCDS41309
HPRD 09869
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca