Version 5.4
Homo sapiens Gene: PLK3
Summary
InnateDB Gene IDBG-97804.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLK3
Gene Name polo-like kinase 3
Synonyms CNK; FNK; PRK
Species Homo sapiens
Ensembl Gene ENSG00000173846
Encoded Proteins
IDBP-97806
polo-like kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008]
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:44800225-44805990
Strand Forward strand
Band p34.1
Transcripts
ENST00000372201 ENSP00000361275
ENST00000465443
ENST00000476731
ENST00000492398
ENST00000461358
ENST00000461769
ENST00000493100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000084 mitotic S phase
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000302 response to reactive oxygen species
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006970 response to osmotic stress
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0007113 endomitotic cell cycle
GO:0009314 response to radiation
GO:0031122 cytoplasmic microtubule organization
GO:0043066 negative regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0051302 regulation of cell division
GO:0090166 Golgi disassembly
GO:0090316 positive regulation of intracellular protein transport
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005813 centrosome
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028680
View Gene Order
ENSBTAG00000006125
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
plk3_pathway
PLK3 signaling events
plk_pathway
Polo-like kinase signaling events in the cell cycle
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632415
RefSeq NM_004073
HUGO
OMIM
CCDS CCDS515
HPRD 04222
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca