Version 5.4
Homo sapiens Gene: USP33
Summary
InnateDB Gene IDBG-99821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP33
Gene Name ubiquitin specific peptidase 33
Synonyms VDU1
Species Homo sapiens
Ensembl Gene ENSG00000077254
Encoded Proteins
IDBP-99823
ubiquitin specific peptidase 33
IDBP-99825
ubiquitin specific peptidase 33
IDBP-99827
ubiquitin specific peptidase 33
IDBP-99829
ubiquitin specific peptidase 33
IDBP-592044
ubiquitin specific peptidase 33
IDBP-584488
ubiquitin specific peptidase 33
IDBP-588423
ubiquitin specific peptidase 33
IDBP-599905
ubiquitin specific peptidase 33
IDBP-593188
ubiquitin specific peptidase 33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77695987-77759852
Strand Reverse strand
Band p31.1
Transcripts
ENST00000370794 ENSP00000359830
ENST00000370793 ENSP00000359829
ENST00000357428 ENSP00000350009
ENST00000370792 ENSP00000359828
ENST00000481579 ENSP00000432392
ENST00000477949
ENST00000472462
ENST00000498328
ENST00000461986
ENST00000462192
ENST00000533928
ENST00000527390 ENSP00000432667
ENST00000531637
ENST00000524536 ENSP00000434441
ENST00000525113
ENST00000528150
ENST00000530709 ENSP00000433283
ENST00000524778 ENSP00000436441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006897 endocytosis
GO:0007411 axon guidance
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0051298 centrosome duplication
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0030891 VCB complex
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025437
View Gene Order
ENSBTAG00000020761
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613016 Hs.743324
RefSeq NM_015017 NM_201624 NM_201626 XM_005270649
HUGO
OMIM
CCDS CCDS678 CCDS679 CCDS680
HPRD 10297
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca