Version 5.4
Homo sapiens Gene: NEXN
Summary
InnateDB Gene IDBG-99841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEXN
Gene Name nexilin (F actin binding protein)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162614
Encoded Proteins
IDBP-99843
nexilin (F actin binding protein)
IDBP-99845
nexilin (F actin binding protein)
IDBP-99847
nexilin (F actin binding protein)
IDBP-226782
nexilin (F actin binding protein)
IDBP-386022
nexilin (F actin binding protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77888513-77943895
Strand Forward strand
Band p31.1
Transcripts
ENST00000334785 ENSP00000333938
ENST00000342754 ENSP00000343928
ENST00000330010 ENSP00000327363
ENST00000401035 ENSP00000383814
ENST00000440324 ENSP00000411902
ENST00000464998
ENST00000480732
ENST00000470735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0051015 actin filament binding
Biological Process
GO:0006468 protein phosphorylation
GO:0030334 regulation of cell migration
GO:0048739 cardiac muscle fiber development
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005856 cytoskeleton
GO:0005924 cell-substrate adherens junction
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039103
View Gene Order
ENSBTAG00000008921
Not yet available
Cross-References
SwissProt Q0ZGT2
TrEMBL B4DDI0 E7ETM8 E7EUA0
UniProt Splice Variant
Entrez Gene 91624
UniGene Hs.612385
RefSeq NM_001172309 NM_144573 XM_005271322 XM_005271323 XM_005271324 XM_005271326
HUGO HGNC:29557
OMIM 613121
CCDS CCDS41351 CCDS53335
HPRD
IMGT
EMBL AC096948 AC138392 AF114264 AK057954 AK293201 AK298565 BC017827 BC055084 BC111395 BC114444 BC114445 DQ464902 S67069
GenPept AAB28815 AAD29607 AAH17827 AAH55084 AAI11396 AAI14445 AAI14446 ABE97925 BAB71622 BAG56741 BAG60759
RNA Seq Atlas 91624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca