InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC7

Summary

InnateDB Gene

IDBG-100234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC7

Gene Name

cell division cycle 7 homolog (S. cerevisiae)

Synonyms

CDC7L1; HsCDC7; Hsk1; huCDC7

Species

Homo sapiens

Ensembl Gene

ENSG00000097046

Encoded Proteins

IDBP-100240

cell division cycle 7 homolog (S. cerevisiae)

IDBP-386681

cell division cycle 7 homolog (S. cerevisiae)

IDBP-386682

cell division cycle 7 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:91500893-91525764

Strand

Forward strand

Band

p22.1

Transcripts

ENST00000234626	ENSP00000234626
ENST00000428239	ENSP00000393139
ENST00000426137	ENSP00000398077
ENST00000497611
ENST00000486509

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0010571	positive regulation of nuclear cell cycle DNA replication
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0044770	cell cycle phase transition
GO:0051301	cell division