Homo sapiens Gene: KCNA2
Summary
InnateDB Gene IDBG-100992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNA2
Gene Name potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2;
Species Homo sapiens
Ensembl Gene ENSG00000177301
Encoded Proteins
potassium voltage-gated channel, shaker-related subfamily, member 2
potassium voltage-gated channel, shaker-related subfamily, member 2
potassium voltage-gated channel, shaker-related subfamily, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:110593580-110631474
Strand Reverse strand
Band p13.3
Transcripts
ENST00000369770 ENSP00000358785
ENST00000316361 ENSP00000314520
ENST00000485317 ENSP00000433109
ENST00000525120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0021633 optic nerve structural organization
GO:0034765 regulation of ion transmembrane transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0044224 juxtaparanode region of axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P16389
TrEMBL A0A024R0D3
UniProt Splice Variant
Entrez Gene 3737
UniGene Hs.248139 Hs.657199 Hs.731191
RefSeq NM_004974 NM_001204269
HUGO HGNC:6220
OMIM 176262
CCDS CCDS827 CCDS55625
HPRD 01443
IMGT
EMBL AL365361 BC043564 CH471122 L02752
GenPept AAA36141 AAH43564 CAH71982 EAW56455 EAW56456
RNA Seq Atlas 3737