Version 5.4
Homo sapiens Gene: SYT6
Summary
InnateDB Gene IDBG-101279.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT6
Gene Name synaptotagmin VI
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134207
Encoded Proteins
IDBP-101281
synaptotagmin VI
IDBP-808862
synaptotagmin VI
IDBP-808873
synaptotagmin VI
IDBP-808874
synaptotagmin VI
IDBP-808876
synaptotagmin VI
IDBP-808877
synaptotagmin VI
IDBP-808879
synaptotagmin VI
IDBP-808880
synaptotagmin VI
IDBP-808881
synaptotagmin VI
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:114089291-114153919
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369547 ENSP00000358560
ENST00000610121 ENSP00000476562
ENST00000607941 ENSP00000476507
ENST00000609117 ENSP00000477344
ENST00000610096 ENSP00000477325
ENST00000610222 ENSP00000476396
ENST00000608203 ENSP00000476616
ENST00000609577 ENSP00000477219
ENST00000608879 ENSP00000476324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0019905 syntaxin binding
GO:0030276 clathrin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0007340 acrosome reaction
GO:0060478 acrosomal vesicle exocytosis
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027849
View Gene Order
ENSBTAG00000018881
Not yet available
Cross-References
SwissProt Q5T7P8
TrEMBL B1AMB6 B1AMB7 I6L9C3 V9GYC4 V9GYY7
UniProt Splice Variant
Entrez Gene 148281
UniGene Hs.370963 Hs.733656
RefSeq NM_001270805 XM_006710376 NM_205848
HUGO HGNC:18638
OMIM 607718
CCDS CCDS871
HPRD 09654
IMGT
EMBL AK056448 AL162594 BC044948 CH471122
GenPept AAH44948 BAG51713 CAI18964 CAM27152 EAW56596 EAW56597
RNA Seq Atlas 148281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca