Homo sapiens Gene: SYT6
Summary
InnateDB Gene IDBG-101279.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT6
Gene Name synaptotagmin VI
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134207
Encoded Proteins
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
synaptotagmin VI
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:114089291-114153919
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369547 ENSP00000358560
ENST00000610121 ENSP00000476562
ENST00000607941 ENSP00000476507
ENST00000609117 ENSP00000477344
ENST00000610096 ENSP00000477325
ENST00000610222 ENSP00000476396
ENST00000608203 ENSP00000476616
ENST00000609577 ENSP00000477219
ENST00000608879 ENSP00000476324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0019905 syntaxin binding
GO:0030276 clathrin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0007340 acrosome reaction
GO:0060478 acrosomal vesicle exocytosis
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL V9GYB1
UniProt Splice Variant
Entrez Gene 148281
UniGene
RefSeq NM_001270805 NM_205848 XM_006710376
HUGO HGNC:18638
OMIM 607718
CCDS CCDS871
HPRD
IMGT
EMBL AL162594
GenPept
RNA Seq Atlas 148281