Homo sapiens Gene: NGF
Summary
InnateDB Gene IDBG-101347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGF
Gene Name nerve growth factor (beta polypeptide)
Synonyms Beta-NGF; HSAN5; NGFB;
Species Homo sapiens
Ensembl Gene ENSG00000134259
Encoded Proteins
nerve growth factor (beta polypeptide)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene\'s expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:115285918-115338236
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369512 ENSP00000358525
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005102 receptor binding
GO:0005163 nerve growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006954 inflammatory response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0010033 response to organic substance
GO:0010193 response to ozone
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0030307 positive regulation of cell growth
GO:0031175 neuron projection development
GO:0031954 positive regulation of protein autophosphorylation
GO:0032455 nerve growth factor processing
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0045786 negative regulation of cell cycle
GO:0046928 regulation of neurotransmitter secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048812 neuron projection morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051388 positive regulation of nerve growth factor receptor signaling pathway
GO:0051402 neuron apoptotic process
GO:0051602 response to electrical stimulus
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000648 positive regulation of stem cell proliferation
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005796 Golgi lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signalling to STAT3 pathway
NGF processing pathway
Signalling by NGF pathway
PI3K/AKT activation pathway
p75NTR regulates axonogenesis pathway
Signalling to p38 via RIT and RIN pathway
p75NTR recruits signalling complexes pathway
NF-kB is activated and signals survival pathway
p75NTR negatively regulates cell cycle via SC1 pathway
Frs2-mediated activation pathway
PLC-gamma1 signalling pathway
Axonal growth stimulation pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
NRAGE signals death through JNK pathway
Ceramide signalling pathway
NRIF signals cell death from the nucleus pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
TRKA activation by NGF pathway
NFG and proNGF binds to p75NTR pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
ARMS-mediated activation pathway
Prolonged ERK activation events pathway
NADE modulates death signalling pathway
Signalling to RAS pathway
Activation of TRKA receptors pathway
KEGG
MAPK signaling pathway pathway
Apoptosis pathway
Neurotrophin signaling pathway pathway
INOH
NGF signaling pathway pathway
GPCR signaling pathway
PID BIOCARTA
Trka receptor signaling pathway [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
Cross-References
SwissProt P01138
TrEMBL
UniProt Splice Variant
Entrez Gene 4803
UniGene Hs.2561
RefSeq NM_002506 XM_006710663 XM_006710664 XM_006710665
HUGO HGNC:7808
OMIM 162030
CCDS CCDS882
HPRD
IMGT
EMBL AB037517 AF150960 AF411526 AL049825 BC032517 BC126148 BC126150 BT019733 CH471122 CR541855 M21062 V01511 X52599
GenPept AAA59931 AAD55975 AAH32517 AAI26149 AAI26151 AAL05874 AAV38538 BAA90437 CAA24755 CAA36832 CAB75625 CAG46653 EAW56629
RNA Seq Atlas 4803