Version 5.4
Homo sapiens Gene: FMO5
Summary
InnateDB Gene IDBG-101809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMO5
Gene Name flavin containing monooxygenase 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131781
Encoded Proteins
IDBP-101811
flavin containing monooxygenase 5
IDBP-101815
flavin containing monooxygenase 5
IDBP-388156
flavin containing monooxygenase 5
IDBP-587915
flavin containing monooxygenase 5
IDBP-603679
flavin containing monooxygenase 5
IDBP-588845
flavin containing monooxygenase 5
IDBP-808878
flavin containing monooxygenase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:147175351-147243050
Strand Reverse strand
Band q21.1
Transcripts
ENST00000254090 ENSP00000254090
ENST00000369272 ENSP00000358277
ENST00000441068 ENSP00000416011
ENST00000478432
ENST00000527849 ENSP00000433742
ENST00000533174 ENSP00000436429
ENST00000533848 ENSP00000432569
ENST00000619062
ENST00000578284 ENSP00000462062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0008150 biological_process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028088
View Gene Order
ENSBTAG00000010841
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00982
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.642706 Hs.658494
RefSeq NM_001144829 NM_001144830 NM_001461 XM_005272946 XM_005272947 XM_005272948 XM_006711245
HUGO
OMIM
CCDS CCDS44209 CCDS44210 CCDS926
HPRD 04904
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca