InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NTRK1

Summary

InnateDB Gene

IDBG-103632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTRK1

Gene Name

neurotrophic tyrosine kinase, receptor, type 1

Synonyms

MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA

Species

Homo sapiens

Ensembl Gene

ENSG00000198400

Encoded Proteins

IDBP-103636

neurotrophic tyrosine kinase, receptor, type 1

IDBP-103638

neurotrophic tyrosine kinase, receptor, type 1

IDBP-245933

neurotrophic tyrosine kinase, receptor, type 1

IDBP-584797

neurotrophic tyrosine kinase, receptor, type 1

IDBP-599454

neurotrophic tyrosine kinase, receptor, type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:156815640-156881850

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000368196	ENSP00000357179
ENST00000358660	ENSP00000351486
ENST00000392302	ENSP00000376120
ENST00000497019	ENSP00000436804
ENST00000489021
ENST00000530298
ENST00000524377	ENSP00000431418
ENST00000533630
ENST00000534682
ENST00000531606

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005166	neurotrophin p75 receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0010465	nerve growth factor receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0043121	neurotrophin binding
GO:0046875	ephrin receptor binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007202	activation of phospholipase C activity
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007568	aging
GO:0007611	learning or memory
GO:0007623	circadian rhythm
GO:0008285	negative regulation of cell proliferation
GO:0009314	response to radiation
GO:0010623	developmental programmed cell death
GO:0010976	positive regulation of neuron projection development
GO:0014823	response to activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019233	sensory perception of pain
GO:0021553	olfactory nerve development
GO:0030183	B cell differentiation
GO:0031667	response to nutrient levels
GO:0032320	positive regulation of Ras GTPase activity
GO:0035094	response to nicotine
GO:0038179	neurotrophin signaling pathway
GO:0038180	nerve growth factor signaling pathway
GO:0042490	mechanoreceptor differentiation
GO:0042493	response to drug
GO:0043068	positive regulation of programmed cell death
GO:0043524	negative regulation of neuron apoptotic process
GO:0045471	response to ethanol
GO:0045766	positive regulation of angiogenesis
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048485	sympathetic nervous system development
GO:0048678	response to axon injury
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051599	response to hydrostatic pressure
GO:0051602	response to electrical stimulus
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060009	Sertoli cell development
GO:0060385	axonogenesis involved in innervation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071316	cellular response to nicotine
GO:0071363	cellular response to growth factor stimulus
GO:1901215	negative regulation of neuron death
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0030424	axon
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0043235	receptor complex