Homo sapiens Gene: NTRK1
Summary
InnateDB Gene IDBG-103632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTRK1
Gene Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA;
Species Homo sapiens
Ensembl Gene ENSG00000198400
Encoded Proteins
neurotrophic tyrosine kinase, receptor, type 1
neurotrophic tyrosine kinase, receptor, type 1
neurotrophic tyrosine kinase, receptor, type 1
neurotrophic tyrosine kinase, receptor, type 1
neurotrophic tyrosine kinase, receptor, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156815640-156881850
Strand Forward strand
Band q23.1
Transcripts
ENST00000368196 ENSP00000357179
ENST00000358660 ENSP00000351486
ENST00000392302 ENSP00000376120
ENST00000497019 ENSP00000436804
ENST00000489021
ENST00000530298
ENST00000524377 ENSP00000431418
ENST00000533630
ENST00000534682
ENST00000531606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 62 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005166 neurotrophin p75 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0010465 nerve growth factor receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0043121 neurotrophin binding
GO:0046875 ephrin receptor binding
GO:0048406 nerve growth factor binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007202 activation of phospholipase C activity
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007568 aging
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0010623 developmental programmed cell death
GO:0010976 positive regulation of neuron projection development
GO:0014823 response to activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019233 sensory perception of pain
GO:0021553 olfactory nerve development
GO:0030183 B cell differentiation
GO:0031667 response to nutrient levels
GO:0032320 positive regulation of Ras GTPase activity
GO:0035094 response to nicotine
GO:0038179 neurotrophin signaling pathway
GO:0038180 nerve growth factor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0043068 positive regulation of programmed cell death
GO:0043524 negative regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0045766 positive regulation of angiogenesis
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048485 sympathetic nervous system development
GO:0048678 response to axon injury
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051599 response to hydrostatic pressure
GO:0051602 response to electrical stimulus
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060009 Sertoli cell development
GO:0060385 axonogenesis involved in innervation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071316 cellular response to nicotine
GO:0071363 cellular response to growth factor stimulus
GO:1901215 negative regulation of neuron death
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signalling to STAT3 pathway
Signalling by NGF pathway
PI3K/AKT activation pathway
Signalling to p38 via RIT and RIN pathway
NGF-independant TRKA activation pathway
Frs2-mediated activation pathway
PLC-gamma1 signalling pathway
Signal Transduction pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
TRKA activation by NGF pathway
ARMS-mediated activation pathway
Prolonged ERK activation events pathway
Signalling to RAS pathway
Activation of TRKA receptors pathway
KEGG
MAPK signaling pathway pathway
Endocytosis pathway
Apoptosis pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Thyroid cancer pathway
INOH
NGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Trka receptor signaling pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
p73 transcription factor network
Cross-References
SwissProt
TrEMBL E9PQG0
UniProt Splice Variant
Entrez Gene 4914
UniGene Hs.406293
RefSeq NM_001012331 NM_001007792 NM_002529
HUGO HGNC:8031
OMIM 164970 191315
CCDS CCDS30891 CCDS30890 CCDS1161
HPRD 01869
IMGT
EMBL AL158169
GenPept
RNA Seq Atlas 4914