Homo sapiens Gene: KIRREL
Summary
InnateDB Gene IDBG-103722.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIRREL
Gene Name kin of IRRE like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183853
Encoded Proteins
kin of IRRE like (Drosophila)
kin of IRRE like (Drosophila)
kin of IRRE like (Drosophila)
kin of IRRE like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:157993273-158100262
Strand Forward strand
Band q23.1
Transcripts
ENST00000360089 ENSP00000353202
ENST00000368173 ENSP00000357155
ENST00000359209 ENSP00000352138
ENST00000368172 ENSP00000357154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017022 myosin binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0007588 excretion
GO:0016337 single organismal cell-cell adhesion
GO:0030838 positive regulation of actin filament polymerization
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
GO:0031253 cell projection membrane
GO:0043198 dendritic shaft
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Nephrin/Neph1 signaling in the kidney podocyte
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272234 Hs.606145 Hs.657006
RefSeq NM_001286349 NM_018240 XM_006711430
HUGO
OMIM
CCDS CCDS1172 CCDS72952
HPRD 06306
IMGT
EMBL
GenPept
RNA Seq Atlas