Homo sapiens Gene: PFDN2
Summary
InnateDB Gene IDBG-104178.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN2
Gene Name prefoldin subunit 2
Synonyms PFD2;
Species Homo sapiens
Ensembl Gene ENSG00000143256
Encoded Proteins
prefoldin subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161100556-161118111
Strand Reverse strand
Band q23.3
Transcripts
ENST00000368010 ENSP00000356989
ENST00000468311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
Experimentally validated
Total 49 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016272 prefoldin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UHV9
TrEMBL B1AQP2
UniProt Splice Variant
Entrez Gene 5202
UniGene
RefSeq NM_012394
HUGO HGNC:8867
OMIM 613466
CCDS CCDS1217
HPRD
IMGT
EMBL AF117237 AF151065 AF165883 AK315736 BC012464 BC047042 CH471121
GenPept AAD47084 AAF17218 AAF36151 AAH12464 AAH47042 BAG38091 EAW52658
RNA Seq Atlas 5202