Version 5.4
| Homo sapiens Gene: F5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-104668.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | F5 | ||||||||||||||||||
| Gene Name | coagulation factor V (proaccelerin, labile factor) | ||||||||||||||||||
| Synonyms | FVL; PCCF; RPRGL1; THPH2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000198734 | ||||||||||||||||||
| Encoded Proteins |
coagulation factor V (proaccelerin, labile factor)
coagulation factor V (proaccelerin, labile factor)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:169514166-169586588 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q24.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Common Pathway pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Hemostasis pathway
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| KEGG |
Complement and coagulation cascades pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P12259 | ||||||||||||||||||
| TrEMBL | C8C1T1 Q1L610 Q2HZZ1 Q8TD21 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2153 | ||||||||||||||||||
| UniGene | Hs.30054 | ||||||||||||||||||
| RefSeq | NM_000130 | ||||||||||||||||||
| HUGO | HGNC:3542 | ||||||||||||||||||
| OMIM | 612309 | ||||||||||||||||||
| CCDS | CCDS1281 | ||||||||||||||||||
| HPRD | 01964 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AJ297255 AK291613 AY046060 AY364535 DQ019941 DQ357212 DQ377944 GQ354889 GQ354890 GQ354891 GQ354892 L32755 L32756 L32757 L32758 L32759 L32760 L32761 L32762 L32763 L32764 L32765 L32766 L32767 L32768 L32769 L32770 L32771 L32772 L32773 L32774 L32775 L32776 L32777 L32778 L32779 M14335 M16967 Z99572 | ||||||||||||||||||
| GenPept | AAA52424 AAB59401 AAB59532 AAL09164 AAQ55063 AAY85741 ABC96776 ABD23003 ACV32685 ACV32686 ACV32687 ACV32688 BAF84302 CAB16748 CAC82573 CAI23065 | ||||||||||||||||||
| RNA Seq Atlas | 2153 | ||||||||||||||||||