Version 5.4
| Homo sapiens Gene: FBXL5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-10508.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FBXL5 | ||||||||||||||||||
| Gene Name | F-box and leucine-rich repeat protein 5 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000118564 | ||||||||||||||||||
| Encoded Proteins |
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:15604539-15681679 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p15.32 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID BIOCARTA | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UKA1 | ||||||||||||||||||
| TrEMBL | D6RB50 D6RBW7 D6RCR7 D6RHC3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 26234 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001193535 NM_001193534 NM_012161 XM_006713959 XM_006713960 | ||||||||||||||||||
| HUGO | HGNC:13602 | ||||||||||||||||||
| OMIM | 605655 | ||||||||||||||||||
| CCDS | CCDS54745 CCDS3415 | ||||||||||||||||||
| HPRD | 05739 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC114744 AC116651 AF142481 AF157323 AF174591 AF176700 AF199420 AK000153 AK295510 BC030656 BX537957 CH471069 | ||||||||||||||||||
| GenPept | AAF03700 AAF04512 AAF09249 AAF66616 AAF67489 AAH30656 AAY40929 BAA90978 BAG58427 CAD97924 EAW92737 EAW92739 | ||||||||||||||||||
| RNA Seq Atlas | 26234 | ||||||||||||||||||