Homo sapiens Gene: FBXL5
Summary
InnateDB Gene IDBG-10508.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL5
Gene Name F-box and leucine-rich repeat protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118564
Encoded Proteins
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:15604539-15681679
Strand Reverse strand
Band p15.32
Transcripts
ENST00000341285 ENSP00000344866
ENST00000412094 ENSP00000408679
ENST00000511441 ENSP00000425027
ENST00000513163 ENSP00000425472
ENST00000507700
ENST00000504837
ENST00000512066 ENSP00000426993
ENST00000503196 ENSP00000425541
ENST00000509314 ENSP00000421070
ENST00000510802 ENSP00000423961
ENST00000507899 ENSP00000422049
ENST00000515679 ENSP00000424423
ENST00000514541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0019005 SCF ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UKA1
TrEMBL D6RB50 D6RBW7 D6RCR7 D6RHC3
UniProt Splice Variant
Entrez Gene 26234
UniGene
RefSeq NM_001193535 NM_001193534 NM_012161 XM_006713959 XM_006713960
HUGO HGNC:13602
OMIM 605655
CCDS CCDS54745 CCDS3415
HPRD 05739
IMGT
EMBL AC114744 AC116651 AF142481 AF157323 AF174591 AF176700 AF199420 AK000153 AK295510 BC030656 BX537957 CH471069
GenPept AAF03700 AAF04512 AAF09249 AAF66616 AAF67489 AAH30656 AAY40929 BAA90978 BAG58427 CAD97924 EAW92737 EAW92739
RNA Seq Atlas 26234