Mus musculus Gene: Fbxl5
Summary
InnateDB Gene IDBG-161237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl5
Gene Name F-box and leucine-rich repeat protein 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039753
Encoded Proteins
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
F-box and leucine-rich repeat protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118564:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43744616-43821639
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000047857 ENSMUSP00000045792
ENSMUST00000087465 ENSMUSP00000084733
ENSMUST00000114047 ENSMUSP00000109681
ENSMUST00000119523 ENSMUSP00000113557
ENSMUST00000121736 ENSMUSP00000112444
ENSMUST00000141902 ENSMUSP00000120338
ENSMUST00000124610 ENSMUSP00000116720
ENSMUST00000140469
ENSMUST00000143316
ENSMUST00000124421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chaperonin-mediated protein folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Metabolism of proteins pathway
Protein folding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.25794 Mm.456609 Mm.457823
RefSeq NM_001159963 NM_178729
OMIM
CCDS CCDS19263 CCDS51489
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas