Version 5.4
| Homo sapiens Gene: SMG7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105301.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SMG7 | ||||||||||||||||||
| Gene Name | smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) | ||||||||||||||||||
| Synonyms | C1orf16; EST1C; SGA56M | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000116698 | ||||||||||||||||||
| Encoded Proteins |
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:183472216-183598246 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q25.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Nonsense-Mediated Decay (NMD) pathway
Gene Expression pathway
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| KEGG |
mRNA surveillance pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001174061 NM_173156 NM_201568 NM_201569 XM_006711674 XM_006711675 XM_006711676 XM_006711677 XM_006711678 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS1355 CCDS41445 CCDS53444 CCDS53445 | ||||||||||||||||||
| HPRD | 10723 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||