Homo sapiens Gene: SMG7
Summary
InnateDB Gene IDBG-105301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMG7
Gene Name smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms C1orf16; EST1C; SGA56M;
Species Homo sapiens
Ensembl Gene ENSG00000116698
Encoded Proteins
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:183472216-183598246
Strand Forward strand
Band q25.3
Transcripts
ENST00000347615 ENSP00000340766
ENST00000367538
ENST00000367537 ENSP00000356507
ENST00000419169 ENSP00000388390
ENST00000440812 ENSP00000410254
ENST00000444547 ENSP00000400220
ENST00000507691 ENSP00000422742
ENST00000508461 ENSP00000426915
ENST00000507469 ENSP00000425133
ENST00000515829 ENSP00000421358
ENST00000502375 ENSP00000422056
ENST00000493609
ENST00000507406
ENST00000493045
ENST00000495321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006406 mRNA export from nucleus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035303 regulation of dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
KEGG
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001174061 NM_173156 NM_201568 NM_201569 XM_006711674 XM_006711675 XM_006711676 XM_006711677 XM_006711678
HUGO
OMIM
CCDS CCDS1355 CCDS41445 CCDS53444 CCDS53445
HPRD 10723
IMGT
EMBL
GenPept
RNA Seq Atlas